Commerce Clause gives Congress the ability to regulate interstate commerce. It does not independently provide federal courts with a basis for jurisdiction. Practically speaking there needs to be either diversity jurisdiction which requires all parties on one side of the action to be citizens of states different from those on the other side of the action. The ACC contends that it is a citizen of all states where the member schools are based. As far as I can tell CU and FSU have not challenged this. Further, there is a 30 day time to move the case to Federal court which is long gone. There is also Federal Question jurisdiction when the action arises questions of Federal law. I’m not aware of any of the parties making this argument nor does it seem to apply. There are lots of nuances but at this point, I don’t see how this ends up in federal court.